Open AccessMicrobleed prevalence and burden in anticoagulant‐associated intracerebral bleed
Author(s) -
Lioutas VasileiosArsenios,
Goyal Nitin,
Katsanos Aristeidis H.,
Krogias Christos,
Zand Ramin,
Sharma Vijay K.,
Varelas Panayiotis,
Malhotra Konark,
Paciaroni Maurizio,
Sharaf Aboubakar,
Chang Jason,
Kargiotis Odysseas,
Pandhi Abhi,
Schroeder Christoph,
Tsantes Argyrios,
Boviatsis Efstathios,
Mehta Chandan,
Mitsias Panayiotis D.,
Selim Magdy H.,
Alexandrov Andrei V.,
Tsivgoulis Georgios
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.50834
Subject(s) - medicine , intracerebral hemorrhage , confounding , bleed , logistic regression , observational study , cohort , cohort study , subarachnoid hemorrhage , surgery
Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation‐related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA‐ICH, 48% in NOAC‐ICH). NOAC‐ICH patients had lower median CMB count [2(IQR:1–3) vs. 7(4–11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC‐ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01–0.83; P = 0.034).