Open AccessMRI biomarkers of proximal nerve injury in CIDP
Author(s) -
Lichtenstein Thorsten,
Sprenger Alina,
Weiss Kilian,
Slebocki Karin,
Cervantes Barbara,
Karampinos Dimitrios,
Maintz David,
Fink Gereon R.,
Henning Tobias D.,
Lehmann Helmar C.
Publication year - 2018
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.502
Subject(s) - medicine , diffusion mri , magnetic resonance imaging , fractional anisotropy , biceps , subclinical infection , sciatic nerve , lumbosacral plexus , tibial nerve , nerve conduction study , magnetic resonance neurography , radiology , anatomy , pathology , nerve conduction , stimulation
Objective To evaluate the utility of nerve diffusion tensor imaging ( DTI ), nerve cross‐sectional area, and muscle magnetic resonance imaging ( MRI ) multiecho Dixon for assessing proximal nerve injury in chronic inflammatory demyelinating polyneuropathy ( CIDP ). Methods In this prospective observational cohort study, 11 patients with CIDP and 11 healthy controls underwent a multiparametric MRI protocol with DTI of the sciatic nerve and assessment of muscle proton‐density fat fraction of the biceps femoris and the quadriceps femoris muscles by multiecho Dixon MRI . Patients were longitudinally evaluated by MRI , clinical examination, and nerve conduction studies at baseline and after 6 months. Results In sciatic nerves of CIDP patients, mean cross‐sectional area was significantly higher and fractional anisotropy value was significantly lower, compared to controls. In contrast, muscle proton‐density fat fraction was significantly higher in thigh muscles of patients with CIDP, compared to controls. MRI parameters showed high reproducibility at baseline and 6 months. Interpretation Advanced MRI parameters demonstrate subclinical proximal nerve damage and intramuscular fat accumulation in CIDP . Data suggest DTI and multiecho Dixon MRI might be useful in estimating axonal damage and neurogenic muscle changes in CIDP .