Open AccessNeural correlates of adaptive working memory training in a glycogen storage disease type‐ IV patient
Author(s) -
Lee Kristin,
Ernst Thomas,
Løhaugen Gro,
Zhang Xin,
Chang Linda
Publication year - 2017
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.394
Subject(s) - medicine , glycogen storage disease , working memory , cognitive training , disease , glycogen , cognition , physical medicine and rehabilitation , psychiatry
Glycogen storage disease type‐ IV has varied clinical presentations and subtypes. We evaluated a 38‐year‐old man with memory complaints, common symptoms in adult polyglucosan body disease subtype, and investigated cognitive and functional MRI changes associated with two 25‐sessions of adaptive working memory training. He showed improved trained and nontrained working memory up to 6‐months after the training sessions. On functional MRI , he showed increased cortical activation 1–3 months after training, but both increased and decreased activation 6‐months later. Working memory training appears to be beneficial to patients with adult polyglucosan body disease, although continued training may be required to maintain improvements.