Open AccessPituitary adenylate cyclase activating polypeptide and migraine
Author(s) -
Zagami Alessandro S.,
Edvinsson Lars,
Goadsby Peter J.
Publication year - 2014
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.113
Subject(s) - medicine , migraine , sumatriptan , cyclase , jugular vein , superior sagittal sinus , vasoactive intestinal peptide , endocrinology , adenylate kinase , receptor , pituitary adenylate cyclase activating peptide , anesthesia , neuropeptide , thrombosis , agonist
Pituitary adenylate cyclase activating peptide ( PACAP ) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus ( SSS ) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache ( n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg ( n = 11), and further reduced interictally ( n = 9). The data suggest PACAP , or its receptors, are a promising target for migraine therapeutics.