Open AccessComparative analysis for renal stereotactic body radiotherapy using Cyberknife, VMAT and proton therapy based treatment planning
Author(s) -
Baydoun Atallah,
Vapiwala Neha,
Ponsky Lee E.,
Awan Musaddiq,
Kassaee Ali,
Sutton David,
Podder Tarun K.,
Zhang Yuxia,
Dobbins Donald,
Muzic Raymond F.,
Traughber Bryan,
Machtay Mitchell,
Ellis Rodney
Publication year - 2018
Publication title -
journal of applied clinical medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.83
H-Index - 48
ISSN - 1526-9914
DOI - 10.1002/acm2.12308
Subject(s) - cyberknife , medicine , nuclear medicine , radiation treatment planning , renal cell carcinoma , radiosurgery , proton therapy , radiation therapy , radiology , oncology
Purpose We conducted this dosimetric analysis to evaluate the feasibility of a multi‐center stereotactic body radiation therapy (SBRT) trial for renal cell carcinoma (RCC) using different SBRT platforms. Materials/methods The computed tomography (CT) simulation images of 10 patients with unilateral RCC previously treated on a Phase 1 trial at Institution 1 were anonymized and shared with Institution 2 after IRB approval. Treatment planning was generated through five different platforms aiming a total dose of 48 Gy in three fractions. These platforms included: Cyberknife and volumetric modulated arc therapy (VMAT) at institution 1, and Cyberknife, VMAT, and pencil beam scanning (PBS) Proton Therapy at institution 2. Dose constraints were based on the Phase 1 approved trial. Results Compared to Cyberknife, VMAT and PBS plans provided overall an equivalent or superior coverage to the target volume, while limiting dose to the remaining kidney, contralateral kidney, liver, spinal cord, and bowel. Conclusion This dosimetric study supports the feasibility of a multi‐center trial for renal SBRT using PBS, VMAT and Cyberknife.