Assessment of radiopharmaceutical retention for vascular access ports using positron emission tomography imaging

Purpose The purpose of this study was to resolve the issue of whether various generations of CR Bard peripheral vascular access ports and catheters are prone to retain PET radiopharmaceuticals. The study evaluates the residual radioactivity remaining following injection for two PET radiopharmaceuticals currently used extensively in the clinic, FDG and Na 18 F. Methods FDG was purchased from a local cyclotron facility and Na 18 F was prepared in‐house. Three generations of currently marketed vascular access ports were tested. A total of five ( n = 5) of each model was tested. Radiopharmaceutical of 2–3 mC i of each was injected into each port and flushed with 10, 30, 60, and 120 ml of saline. Micro PET scans were performed after each flush to detect the residual radioactivity on each port. A dose calibrator was used to detect the retention of radioactivity after each flush. Results Radioactivity retention for all vascular port models measured by micro PET imaging was similar for both FDG and Na 18 F, with less than 1% residual activity following a 10 ml saline flush. Based on the micro PET images, all the subsequent flushes of 30, 60, and 120 ml were also considered. Dose calibrator activity measurements validated micro PET measurements as negligible for all the ports, even with the first 10 ml flush. Conclusions Micro PET imaging was more sensitive than the dose calibrator in determining the radioactivity retention of the vascular access ports from CR Bard. These ports may be used for the injection of FDG and Na 18 F to track glucose metabolism and bone uptake with PET imaging. It is recommended to apply at least a 10 ml flush after radiopharmaceutical administration, to reduce residual activity to baseline levels.