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Differential sensitivity to the effects of nicotine and bupropion in adolescent and adult male OF1 mice during social interaction tests
Author(s) -
Gómez M.C.,
Carrasco M.C.,
Redolat R.
Publication year - 2008
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/ab.20255
Subject(s) - bupropion , nicotine , psychology , differential effects , developmental psychology , adult male , statistical significance , analysis of variance , physiology , medicine , psychiatry , smoking cessation , pathology
Few studies have compared the action of both nicotine (NIC) and bupropion (BUP), an antidepressant used to treat NIC dependence, on social and aggressive behavior at different ages. This study aims to determine whether these drugs produce differential effects in adolescent (postnatal day: 36–37) and adult (postnatal day: 65–66) mice that have been housed individually for 2 weeks in order to induce aggressive behavior. Mice received BUP (40, 20, or 10 mg/kg), NIC (1, 0.5, and 0.25 mg/kg as base), or vehicle earlier to a social interaction test. BUP (40 mg/kg) decreased social investigation and increased nonsocial exploration in both adolescent and adult mice. The same effects were also observed in adult mice administered with a lower dose of the same drug (20 mg/kg). In adolescents, NIC (1 mg/kg) decreased social investigation, but this effect did not reach statistical significance in adults. In conclusion, a differential sensitivity to the effects of NIC or BUP emerged in some of the behavioral categories when the two age groups were compared. Aggr. Behav. 34:369–379, 2008. © 2008 Wiley‐Liss, Inc.