Open AccessPaired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
Author(s) -
Gao Jie,
Ma Kangjie,
Zhang Li,
Li Tao,
Zhao Baodong,
Jiang Yaping
Publication year - 2022
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13367
Subject(s) - autophagy , adenoid cystic carcinoma , homeobox , acetyl coa carboxylase , reprogramming , pyruvate carboxylase , biology , cancer research , lipid metabolism , metabolism , metastasis , biochemistry , chemistry , endocrinology , carcinoma , enzyme , cancer , cell , transcription factor , gene , apoptosis , genetics
Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial‐mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty acids (FFAs). However, the effect of FFA metabolism on autophagy in SACC remains unknown. In this study, we showed that overexpression of paired related homeobox 1 (PRRX1) reduced the number of autophagosomes and decreased the expression of LC3 and Beclin‐1 in SACC patients and SACC‐83 cells in vitro . Moreover, PRRX1‐mediating FFA reprogramming triggered to autophagy via regulating acetyl‐CoA carboxylase 1 (ACC1), leading to invasion and migration in SACC.