Open AccessFerritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
Author(s) -
Ali Amjad,
Shafarin Jasmin,
Abu Jabal Rola,
Aljabi Nour,
Hamad Mohamad,
Sualeh Muhammad Jibran,
Unnikannan Hema,
Hamad Mawieh
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13303
Subject(s) - gene silencing , cell growth , cancer research , ferritin , breast cancer , triple negative breast cancer , chemistry , suppressor , in vitro , cancer , biology , biochemistry , gene , genetics
Overexpression of ferritin heavy chain ( FTH1 ) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype (triple‐negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 silencing or overexpression on several aspects of BCa cell growth in vitro . FTH1 silencing promoted cell growth and mammosphere formation, increased c‐MYC expression, and reduced cell sensitivity to chemotherapy. In contrast, FTH1 overexpression inhibited cell growth, decreased c‐MYC expression, and sensitized cancer cells to chemotherapy; silencing of c‐MYC recapitulated the effects of FTH1 overexpression. These findings show for the first time that FTH1 suppresses tumor growth by inhibiting the expression of key oncogenes, such as c‐MYC .