Open AccessResilience to social stress: is it in the blood?
Author(s) -
Bogeska Ruzhica
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13291
Subject(s) - social defeat , social stress , stressor , neuropathology , extracellular vesicles , microvesicles , microglia , psychological resilience , extracellular , neuroscience , immunology , microrna , psychology , biology , inflammation , microbiology and biotechnology , medicine , social psychology , genetics , disease , gene
In social mammalian species, social stress can arise from different social interactions. Repeated exposure to social stressors can lead to neuropathology and psychiatric disorders. In this issue, Sakamoto et al . report on alterations in extracellular vesicles (EVs) in a mouse model of chronic social defeat stress (CSDS). The data suggest that mice susceptible to CSDS have alterations in the miRNA content of circulating EVs, which influences the expression of pro‐inflammatory cytokines in microglia cells.