Open AccessPorphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells
Author(s) -
Miya Chihiro,
Cueno Marni E.,
Suzuki Ryuta,
Maruoka Shuichiro,
Gon Yasuhiro,
Kaneko Tadayoshi,
Yonehara Yoshiyuki,
Imai Kenichi
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13066
Subject(s) - porphyromonas gingivalis , microbiology and biotechnology , fimbria , virulence , lipopolysaccharide , virulence factor , mutant , biology , gene expression , gene , chemistry , immunology , bacteria , biochemistry , genetics
MUC5AC gene expression and protein levels are affected by Pg culture supernatant, but not by lipopolysaccharide or FimA fimbriae. Cells treated with either Pg single (Kgp or Rgp) or double (Kgp/Rgp) mutants had altered levels of MUC5AC gene expression and protein levels, and MUC5AC staining of double mutant‐treated mouse lung cells showed that MUC5AC protein levels were unaffected.