Open AccessmicroRNA‐637 promotes apoptosis and suppresses proliferation and autophagy in multiple myeloma cell lines via NUPR1
Author(s) -
Chen Xuanxin,
Li Anmao,
Zhan Qian,
Jing Zizi,
Chen Yiyu,
Chen Jianbin
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13063
Subject(s) - microrna , apoptosis , western blot , autophagy , cell growth , chemistry , luciferase , cancer research , cell culture , pathogenesis , reporter gene , blot , multiple myeloma , microbiology and biotechnology , transfection , biology , gene expression , gene , immunology , biochemistry , genetics
Multiple myeloma (MM) is a heterogeneous disease with poor prognosis. Increasing evidence has revealed that microRNAs (miRNAs) are strongly associated with the pathogenesis and progression of MM. MiR‐637 promotes apoptosis and suppresses cell proliferation and autophagy in multiple myeloma by targeting NUPR1. This study provides a novel possible therapeutic target for MM.