Open AccessAlpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient ( PARK4 ) with SNCA triplication
Author(s) -
Fukusumi Hayato,
Togo Kazuyuki,
Sumida Miho,
Nakamori Masayuki,
Obika Satoshi,
Baba Kousuke,
Shofuda Tomoko,
Ito Daisuke,
Okano Hideyuki,
Mochizuki Hideki,
Kanemura Yonehiro
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13060
Subject(s) - substantia nigra , pars compacta , induced pluripotent stem cell , dopaminergic , parkinson's disease , alpha synuclein , biology , neuroscience , disease , dopamine , medicine , pathology , genetics , gene , embryonic stem cell
Alpha‐synuclein is a major component of Lewy bodies, which are a histological hallmark of Parkinson's disease (PD). In this study, we investigated the dynamics of α‐synuclein during the early stage of immature dopaminergic neurons differentiated from human‐induced pluripotent stem cells derived from either a PD patient with SNCA triplication or a healthy donor.