Reduced RING finger protein 10 expression in macrophages is associated with aging‐related inflammation | Zendy

Cao Xinyuan | Zendy; Liu Lidan | Zendy; Zhang Yueyi | Zendy; Yang Yingyun | Zendy

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Reduced RING finger protein 10 expression in macrophages is associated with aging‐related inflammation

Author(s) -

Cao Xinyuan,

Liu Lidan,

Zhang Yueyi,

Yang Yingyun

Publication year - 2021

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.13049

Subject(s) - immunosenescence , proinflammatory cytokine , inflammation , immune system , immunology , ring finger , innate immune system , biology , lipopolysaccharide , macrophage , microbiology and biotechnology , medicine , genetics , gene , in vitro

The understanding of the mechanism governing the onset of immunosenescence remains incomplete. Here, we found that RNF10 could be suppressed by increased TLR‐TRIF pathway activation and maintained at a low level in aged macrophages compared with young cells. Moreover, reduced RNF10 increased lipopolysaccharide‐triggered signaling pathways of nuclear factor‐κB and interferon regulatory factor 3, thereby enhancing proinflammatory cytokines and interferons in aged cells.

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