Open AccessReduced RING finger protein 10 expression in macrophages is associated with aging‐related inflammation
Author(s) -
Cao Xinyuan,
Liu Lidan,
Zhang Yueyi,
Yang Yingyun
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13049
Subject(s) - inflammation , ring finger , ring (chemistry) , protein expression , microbiology and biotechnology , macrophage , biology , chemistry , biochemistry , immunology , gene , organic chemistry , in vitro
The understanding of the mechanism governing the onset of immunosenescence remains incomplete. Here, we found that RNF10 could be suppressed by increased TLR‐TRIF pathway activation and maintained at a low level in aged macrophages compared with young cells. Moreover, reduced RNF10 increased lipopolysaccharide‐triggered signaling pathways of nuclear factor‐κB and interferon regulatory factor 3, thereby enhancing proinflammatory cytokines and interferons in aged cells.