Open AccessThe Hepatitis C virus NS5A and core proteins exert antagonistic effects on HAMP gene expression: the hidden interplay with the MTF‐1/MRE pathway
Author(s) -
Dimitriadis Alexios,
Foka Pelagia,
Kyratzopoulou Eleni,
Karamichali Eirini,
Petroulia Stavroula,
Tsitoura Panagiota,
Kakkanas Athanasios,
Eliadis Petros,
Georgopoulou Urania,
Mamalaki Avgi
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13048
Subject(s) - hepcidin , hamp , ns5a , biology , ferroportin , microbiology and biotechnology , hepatitis c virus , immunology , virus , inflammation , hepacivirus
During HCV infection, the multifunctional core and NS5A viral proteins regulate the iron‐regulatory hormone hepcidin expression antagonistically. While hepcidin is enhanced by core‐mediated activation of BMP/SMAD and STAT3 pathways, it is down‐regulated by NS5A independently of these factors. Herein, we show that NS5A disturbs the MTF‐1/Zn 2+ /hepcidin positive regulation axis, by mopping up Zn 2+ , thereby preserving the structural integrity of NS5A dimers.