Open AccessAsn‐linked N–acetylglucosamine of the amylin receptor 2 extracellular domain enhances peptide ligand affinity
Author(s) -
Lee Sangmin
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13042
Subject(s) - amylin , peptide , chemistry , calcitonin receptor , biochemistry , receptor , glycan , biology , glycoprotein , neuropeptide , calcitonin gene related peptide , endocrinology , islet , insulin
The amylin receptor 2 is the complex of the calcitonin receptor and an accessary protein called receptor activity‐modifying protein 2. The current study shows that the asparagine (Asn)‐linked N ‐acetylglucosamine (GlcNAc) of the calcitonin receptor significantly enhances peptide ligand affinity for the amylin receptor 2 extracellular domain.