Open AccessDelivery of a mitochondria‐targeted antioxidant from biocompatible, polymeric nanofibrous scaffolds
Author(s) -
Hamedani Yasaman,
Teixeira Rayane Brinck,
Karbasiafshar Catherine,
Wipf Peter,
Bhowmick Sankha,
Abid M. Ruhul
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13032
Subject(s) - reactive oxygen species , antioxidant , mitochondrial ros , mitochondrion , chemistry , plga , nanofiber , biocompatible material , microbiology and biotechnology , drug delivery , scaffold , in vitro , pharmacology , biochemistry , nanotechnology , materials science , biology , medicine , biomedical engineering , organic chemistry
Using electrospinning, we fabricated a biocompatible nanofibrous scaffold with mitochondrial antioxidant JP4‐039. Electron paramagnetic resonance spectroscopy tracked an initial burst release of JP4‐039 within the first 20 min followed by a sustained release over 72 h. The released drug reduced mitochondrial reactive oxygen species and induced migration and tube formation in human coronary artery endothelial cells, suggesting therapeutic potential of the implants.