Open AccessMegf10 deficiency impairs skeletal muscle stem cell migration and muscle regeneration
Author(s) -
Li Chengcheng,
VargasFranco Dorianmarie,
Saha Madhurima,
Davis Rachel M.,
Manko Kelsey A.,
Draper Isabelle,
Pacak Christina A.,
Kang Peter B.
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13031
Subject(s) - skeletal muscle , myopathy , regeneration (biology) , biology , endocrinology , medicine , microbiology and biotechnology , pathology , anatomy , genetics
The exact disease mechanism of MEGF10 deficiency, which causes a rare inherited myopathy, remains unknown. In mice, Megf10 deficiency is associated with slower proliferation and migration of satellite cells, as well as impaired skeletal muscle regeneration after skeletal muscle injury experiments. These studies demonstrate that Megf10 makes important contributions to the function of satellite cells in muscle regeneration.