IFI44L expression is regulated by IRF‐1 and HIV‐1 | Zendy

Li Yutong | Zendy; Zhang Junshi | Zendy; Wang Chenchen | Zendy; Qiao Wentao | Zendy; Li Yue | Zendy; Tan Juan | Zendy

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IFI44L expression is regulated by IRF‐1 and HIV‐1

Author(s) -

Li Yutong,

Zhang Junshi,

Wang Chenchen,

Qiao Wentao,

Li Yue,

Tan Juan

Publication year - 2021

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.13030

Subject(s) - promoter , transcription factor , transcription (linguistics) , interferon , biology , transfection , innate immune system , response element , gene , interferon regulatory factors , microbiology and biotechnology , clone (java method) , gene expression , immune system , genetics , linguistics , philosophy

Interferon (IFN)‐inducible 44 like (IFI44L) is an IFN‐stimulated gene, the expression of which is induced by IFN and human immunodeficiency virus (HIV)‐1 infection. However, the mechanism has not yet been determined. In this study, we cloned the promoter of the IFI44L gene and found that interferon regulatory factor‐1 could bind directly to the IFN‐stimulated response element in the IFI44L promoter to activate IFI44L. Furthermore, we demonstrated that HIV‐1 can activate the IFI44L promoter to influence the expression of IFI44L.

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