Open AccessIFI44L expression is regulated by IRF‐1 and HIV‐1
Author(s) -
Li Yutong,
Zhang Junshi,
Wang Chenchen,
Qiao Wentao,
Li Yue,
Tan Juan
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13030
Subject(s) - human immunodeficiency virus (hiv) , biology , microbiology and biotechnology , computational biology , virology
Interferon (IFN)‐inducible 44 like (IFI44L) is an IFN‐stimulated gene, the expression of which is induced by IFN and human immunodeficiency virus (HIV)‐1 infection. However, the mechanism has not yet been determined. In this study, we cloned the promoter of the IFI44L gene and found that interferon regulatory factor‐1 could bind directly to the IFN‐stimulated response element in the IFI44L promoter to activate IFI44L. Furthermore, we demonstrated that HIV‐1 can activate the IFI44L promoter to influence the expression of IFI44L.