Open AccessPrefoldin subunit 6 of Plasmodium falciparum binds merozoite surface protein‐1
Author(s) -
Kumar Vikash,
Shoaib Rumaisha,
Behl Ankita,
Munjal Akshay,
Abid Mohammad,
Singh Shailja
Publication year - 2022
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13022
Subject(s) - plasmodium falciparum , biology , merozoite surface protein , in silico , protein subunit , microbiology and biotechnology , gene , protozoa , chaperonin , plasmodium (life cycle) , protein folding , malaria , parasite hosting , genetics , malaria vaccine , immunology , world wide web , computer science
Prefoldin is a cochaperone that delivers unfolded proteins to chaperonin for proper folding. Here, we have characterized prefoldin‐6 subunit (PfPFD‐6) of Plasmodium falciparum . PfPFD‐6 is expressed during asexual blood stages and interacts with merozoite surface protein‐1 (MSP‐1), a key protein involved in erythrocyte invasion by the malaria parasite. Our study suggests that PfPFD‐6 may play a role in stabilizing or trafficking MSP‐1.