Open AccessCardiac pericytes function as key vasoactive cells to regulate homeostasis and disease
Author(s) -
Lee Linda L.,
Khakoo Aarif Y.,
Chintalgattu Vishnu
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13021
Subject(s) - microbiology and biotechnology , mural cell , biology , homeostasis , endocrinology , cd31 , medicine , angiogenesis , vascular smooth muscle , cancer research , smooth muscle
Pericytes (PCs) in general are known to help maintain vessel integrity; however, their specific function in the heart is not well defined. Our in vitro study details NG2 + PDGFRβ + CD146 + CD34 − CD31 − CD45 − cardiac PC phenotypic and functional characteristics, and their role in vasoregulation in physiological and disease prone environments. Cardiac PCs can potentially regulate blood flow in the heart.