Cardiac pericytes function as key vasoactive cells to regulate homeostasis and disease | Zendy

Lee Linda L. | Zendy; Khakoo Aarif Y. | Zendy; Chintalgattu Vishnu | Zendy

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Cardiac pericytes function as key vasoactive cells to regulate homeostasis and disease

Author(s) -

Lee Linda L.,

Khakoo Aarif Y.,

Chintalgattu Vishnu

Publication year - 2021

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.13021

Subject(s) - microbiology and biotechnology , mural cell , biology , homeostasis , endocrinology , cd31 , medicine , angiogenesis , vascular smooth muscle , cancer research , smooth muscle

Pericytes (PCs) in general are known to help maintain vessel integrity; however, their specific function in the heart is not well defined. Our in vitro study details NG2 + PDGFRβ + CD146 + CD34 − CD31 − CD45 − cardiac PC phenotypic and functional characteristics, and their role in vasoregulation in physiological and disease prone environments. Cardiac PCs can potentially regulate blood flow in the heart.

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