Open AccessAquaporin 1 mediates early responses to osmotic stimuli in endothelial cells via the calmodulin pathway
Author(s) -
Jiang Yong,
Wang Chengqi,
Ma Rui,
Zhao Ying,
Ma Xinyue,
Wan Jiaxin,
Li Chunxiang,
Chen Fanghao,
Fang Fang,
Li Mingguang
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13020
Subject(s) - calmodulin , aquaporin , microbiology and biotechnology , osmotic shock , chemistry , biology , biochemistry , gene , enzyme
Upon exposure to osmotic stimuli, AQP1 is phosphorylated and translocates to the cell membrane. After the initial response, the Ca2+/CaMK2 pathway is activated to regulate membrane localization and the activity of AQP1, which leads to a change in cell size and adjustment to the environment. These changes are blocked by the calmodulin antagonist W‐7.