Open AccessJDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4–DR5 axis
Author(s) -
Engler Máté János,
Mimura Junsei,
Yamazaki Shun,
Itoh Ken
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13017
Subject(s) - atf4 , gene knockdown , hela , transcription factor , apoptosis , repressor , activator (genetics) , cancer research , microbiology and biotechnology , chemistry , unfolded protein response , biology , gene , cell , biochemistry
Here, we found transcriptional repressor JDP2 is transcriptionally induced by ATF4 via AARE in the JDP2 promoter. JDP2 functions as a negative feedback regulator of the ATF4 pathway and suppresses ATF4‐mediated death receptor DR5 expression. JDP2 suppresses TRAIL‐mediated apoptosis by inhibiting the ATF4‐DR5 axis.