Open AccessGDF15 knockdown suppresses cervical cancer cell migration in vitro through the TGF‐β/Smad2/3/Snail1 pathway
Author(s) -
Li Li,
Zhang Ruihong,
Yang Hailei,
Zhang Donghua,
Liu Jiwei,
Li Jinfang,
Guo Bin
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13013
Subject(s) - gene knockdown , hela , transforming growth factor , cell migration , cancer research , transfection , cancer cell , gdf15 , microbiology and biotechnology , cell growth , vimentin , smad , biology , cell , cell culture , cancer , chemistry , endocrinology , immunology , immunohistochemistry , biochemistry , genetics
The expression of growth differentiation factor 15 (GDF15) is increased in cervical cancer tissues, especially in metastatic cervical cancer tissue, as well as cultivated cells. Knockdown of GDF15 markedly affects epithelial–mesenchymal transformation‐related gene expression and suppresses the migration and invasion abilities of cervical cancer cells through the transforming growth factor‐β/Smad2/3/Snail1 pathway.