Open AccessIL35 predicts prognosis in gastric cancer and is associated with angiogenesis by altering TIMP1, PAI1 and IGFBP1
Author(s) -
Li Xiao,
Niu Nan,
Sun Jing,
Mou Yiping,
He Xujun,
Mei Linhang
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13005
Subject(s) - angiogenesis , metastasis , cancer research , umbilical vein , thrombomodulin , human umbilical vein endothelial cell , cancer , neovascularization , medicine , biology , endocrinology , in vitro , thrombin , biochemistry , platelet
Interleukin‐35 (IL35) is a dimer composed of IL12A and EBV‐induced gene 3. Here, we report that expression of IL35 is correlated with higher microvessel density, distant metastasis and poor prognosis in gastric cancer. Moreover, IL35 is involved in angiogenesis. IL12A is the dominant subunit in the promotion of tube formation.