IL35 predicts prognosis in gastric cancer and is associated with angiogenesis by altering TIMP1, PAI1 and IGFBP1 | Zendy

Li Xiao | Zendy; Niu Nan | Zendy; Sun Jing | Zendy; Mou Yiping | Zendy; He Xujun | Zendy; Mei Linhang | Zendy

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IL35 predicts prognosis in gastric cancer and is associated with angiogenesis by altering TIMP1, PAI1 and IGFBP1

Author(s) -

Li Xiao,

Niu Nan,

Sun Jing,

Mou Yiping,

He Xujun,

Mei Linhang

Publication year - 2020

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.13005

Subject(s) - angiogenesis , metastasis , cancer research , umbilical vein , human umbilical vein endothelial cell , neovascularization , cancer , medicine , vascular endothelial growth factor , endocrinology , biology , chemistry , in vitro , vegf receptors , biochemistry

Interleukin‐35 (IL35) is a dimer composed of IL12A and EBV‐induced gene 3. Here, we report that expression of IL35 is correlated with higher microvessel density, distant metastasis and poor prognosis in gastric cancer. Moreover, IL35 is involved in angiogenesis. IL12A is the dominant subunit in the promotion of tube formation.

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