Open AccessChemical and molecular bases of dome formation in human colorectal cancer cells mediated by sulphur compounds from Cucumis melo var. conomon
Author(s) -
Kamimura Miyu,
Sasaki Azusa,
Watanabe Shimpei,
Tanaka Shiho,
Fukukawa Akiko,
Takeda Kazuya,
Nakamura Yasushi,
Nakamura Takako,
Kuramochi Kouji,
Otani Yui,
Hashimoto Fumio,
Ishimaru Kanji,
Matsuo Tomoaki,
Okamoto Shigehisa
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13001
Subject(s) - colorectal cancer , cell cycle , cancer , cucumis , biology , kinase , cancer research , biochemistry , chemistry , cell , botany , genetics
This study showed that methylthioacetic acid (MTA), an analogue of the sulphur‐containing phytochemicals isolated from Cucumis melo var. conomon , most potently differentiated RCM‐1 colon cancer cells into domes. MTA was shown to strongly down‐regulate CDC25A and CCNE2 , and their inhibitors prompted dome formation independently of MTA, suggesting that MTA may induce dome formation through dysfunction of these G1 regulators.