Open AccessULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3
Author(s) -
Ji Xinmiao,
Zhang Xin,
Li Zhiyuan
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.13000
Subject(s) - autophagy , prophase , microbiology and biotechnology , mitosis , microtubule , chromatin , histone h3 , chemistry , histone , phosphorylation , cancer research , biology , biochemistry , dna , gene , apoptosis , meiosis
Previous reports have demonstrated that SBI‐0206965/MRT68921 inhibit autophagy through unc‐51‐like autophagy activating kinase 1 inhibition. Herein, we report their new function in mitotic dysregulation, mediating spindle microtubule disorganization and phosphorylation of histone H3 (Ser10). This finding may provide insights into tumor treatment with the ULK1 inhibitors.