ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3 | Zendy

Ji Xinmiao | Zendy; Zhang Xin | Zendy; Li Zhiyuan | Zendy

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ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3

Author(s) -

Ji Xinmiao,

Zhang Xin,

Li Zhiyuan

Publication year - 2020

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.13000

Subject(s) - autophagy , prophase , microbiology and biotechnology , mitosis , histone h3 , microtubule , chromatin , histone , chemistry , phosphorylation , cancer research , biology , biochemistry , dna , apoptosis , meiosis , gene

Previous reports have demonstrated that SBI‐0206965/MRT68921 inhibit autophagy through unc‐51‐like autophagy activating kinase 1 inhibition. Herein, we report their new function in mitotic dysregulation, mediating spindle microtubule disorganization and phosphorylation of histone H3 (Ser10). This finding may provide insights into tumor treatment with the ULK1 inhibitors.

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