Intracellular microRNA expression patterns influence cell death fates for both necrosis and apoptosis | Zendy

Sato Akira | Zendy; Yamamoto Akihiro | Zendy; Shimotsuma Akira | Zendy; Ogino Yoko | Zendy; Funayama Naoki | Zendy; Takahashi Yui | Zendy; Hiramoto Akiko | Zendy; Wataya Yusuke | Zendy; Kim HyeSook | Zendy

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Intracellular microRNA expression patterns influence cell death fates for both necrosis and apoptosis

Author(s) -

Sato Akira,

Yamamoto Akihiro,

Shimotsuma Akira,

Ogino Yoko,

Funayama Naoki,

Takahashi Yui,

Hiramoto Akiko,

Wataya Yusuke,

Kim HyeSook

Publication year - 2020

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.12995

Subject(s) - programmed cell death , apoptosis , geldanamycin , microrna , microbiology and biotechnology , gene knockdown , dicer , necrosis , intracellular , biology , cell , cell culture , heat shock protein , small interfering rna , chemistry , transfection , hsp90 , genetics , gene

We reveal that intracellular miRNA expression patterns are dramatically altered in necrosis and apoptosis using a floxuridine (FUdR)‐induced mouse mammary tumor cell death model. We found that knockdown of Dicer in FUdR‐treated necrosis‐fated cells caused a partial shift from necrosis to apoptosis. These findings suggest that the expression of miRNA(s) regulates cell death fate toward necrosis or apoptosis.

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