Open AccessIntracellular microRNA expression patterns influence cell death fates for both necrosis and apoptosis
Author(s) -
Sato Akira,
Yamamoto Akihiro,
Shimotsuma Akira,
Ogino Yoko,
Funayama Naoki,
Takahashi Yui,
Hiramoto Akiko,
Wataya Yusuke,
Kim HyeSook
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12995
Subject(s) - programmed cell death , microrna , apoptosis , geldanamycin , microbiology and biotechnology , dicer , gene knockdown , necrosis , intracellular , biology , cell , heat shock protein , cell culture , chemistry , small interfering rna , transfection , hsp90 , genetics , gene
We reveal that intracellular miRNA expression patterns are dramatically altered in necrosis and apoptosis using a floxuridine (FUdR)‐induced mouse mammary tumor cell death model. We found that knockdown of Dicer in FUdR‐treated necrosis‐fated cells caused a partial shift from necrosis to apoptosis. These findings suggest that the expression of miRNA(s) regulates cell death fate toward necrosis or apoptosis.