Open AccessSHP2 knockdown ameliorates liver insulin resistance by activating IRS‐2 phosphorylation through the AKT and ERK1/2 signaling pathways
Author(s) -
Yue Xinxin,
Han Tao,
Hao Wei,
Wang Min,
Fu Yang
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12992
Subject(s) - protein kinase b , insulin resistance , phosphorylation , gene knockdown , insulin receptor , medicine , endocrinology , irs1 , mapk/erk pathway , kinase , insulin , chemistry , cancer research , biology , apoptosis , biochemistry
Here, we report that SHP2 knockdown enhances glucose consumption, ameliorates insulin resistance, activates IRS‐2 and AKT, and inhibits ERK1/2 phosphorylation in liver.