Open AccessMiR‐17‐3p inhibits osteoblast differentiation by downregulating Sox6 expression
Author(s) -
Chen Nan,
Wu Di,
Li Hua,
Liu Yi,
Yang Hao
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12979
Subject(s) - osteoblast , bone morphogenetic protein 2 , alkaline phosphatase , runx2 , osteopontin , mesenchymal stem cell , microbiology and biotechnology , chemistry , cellular differentiation , microrna , osteocalcin , biology , immunology , in vitro , gene , biochemistry , enzyme
An in vitro model of osteogenesis was established by treating MC3T3‐E1 murine preosteoblast cells with BMP2. MiR‐17‐3p inhibited the differentiation of MC3T3‐E1 cells. Sox6 was confirmed to be a target gene of miR‐17‐3p, and the inhibitory effect of miR‐17‐3p on osteoblast differentiation was reversed by Sox6 . These results suggest potential implications for the treatment of orthopedic disorders.