Open AccessDissecting the transactivation domain (tAD) of the transcription factor c‐Myb to assess recent models of tAD function
Author(s) -
Næs Guro,
Storesund Jan Ove,
Udayakumar PriyangaDina,
Ledsaak Marit,
Gabrielsen Odd Stokke
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12978
Subject(s) - transactivation , mutant , myb , transcription factor , regulator , computational biology , biology , master regulator , transcription (linguistics) , gene , genetics , microbiology and biotechnology , linguistics , philosophy
Genes are activated by transcription factors through their transactivation domains (tADs); disordered regions that have been poorly understood. New models for tADs have recently been proposed. Here, these models were assessed through a mutational analysis of the tAD of the master regulator c‐Myb. Analysis in mammalian cells strongly supported the ‘SLM‐exposure model’. In yeast, tAD mutants behaved quite differently.