Knockout of cytochrome P450 1A1 enhances lipopolysaccharide‐induced acute lung injury in mice by targeting NF‐κB activation | Zendy

Tian Lixing | Zendy; Tang Xin | Zendy; Ma Wei | Zendy; Wang Jing | Zendy; Zhang Wei | Zendy; Liu Kuan | Zendy; Chen Tao | Zendy; Zhu Junyu | Zendy; Liang Huaping | Zendy

Open Access

Knockout of cytochrome P450 1A1 enhances lipopolysaccharide‐induced acute lung injury in mice by targeting NF‐κB activation

Author(s) -

Tian Lixing,

Tang Xin,

Ma Wei,

Wang Jing,

Zhang Wei,

Liu Kuan,

Chen Tao,

Zhu Junyu,

Liang Huaping

Publication year - 2020

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.12977

Subject(s) - lipopolysaccharide , lactate dehydrogenase , hyperoxia , nitric oxide , lung , creatine kinase , knockout mouse , nitric oxide synthase , inflammation , chemistry , medicine , pharmacology , endocrinology , biochemistry , enzyme , receptor

CYP1A1 was induced in lung of mice by LPS treatment with an aryl hydrocarbon receptor‐independent manner, while Toll‐like receptor 4 knockout abolished CYP1A1 overexpression. CYP1A1 deficiency elevated pro‐inflammatory cytokines in lung tissues of septic mice by targeting NF‐κB (p65) and increased lung injury in response to LPS or E . coli challenge.

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