Lumican promotes joint fibrosis through TGF‐β signaling | Zendy

Xiao Dahai | Zendy; Liang Tangzhao | Zendy; Zhuang Ze | Zendy; He Ronghan | Zendy; Ren Jianhua | Zendy; Jiang Shihai | Zendy; Zhu Lei | Zendy; Wang Kun | Zendy; Shi Dehai | Zendy

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Lumican promotes joint fibrosis through TGF‐β signaling

Author(s) -

Xiao Dahai,

Liang Tangzhao,

Zhuang Ze,

He Ronghan,

Ren Jianhua,

Jiang Shihai,

Zhu Lei,

Wang Kun,

Shi Dehai

Publication year - 2020

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.12974

Subject(s) - lumican , transforming growth factor , fibrosis , joint (building) , medicine , transforming growth factor beta , signal transduction , computational biology , cancer research , biology , microbiology and biotechnology , computer science , extracellular matrix , proteoglycan , engineering , decorin , architectural engineering

Proposed mechanisms for lumican in joint contracture include: (a) increased lumican with posttraumatic damage that has caused a transition from a normal joint capsule to joint contracture; and (b) stimulating synovial fibroblasts with recombinant lumican leads to increased transcription of alpha‐smooth muscle actin, matrix metallopeptidase 9, Collagen I, plasminogen activator inhibitor 1 and transforming growth factor‐β in vitro , possibly through the transforming growth factor‐β pathway. Thus, lumican may affect capsule fibrosis in joint contracture.

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