Open AccessDiverse CBX family members as potential prognostic biomarkers in non‐small‐cell lung cancer
Author(s) -
Xie Xiaobin,
Ning Yue,
Long Jie,
Wang Hongyan,
Chen Xiaowei
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12971
Subject(s) - lung cancer , biology , biomarker , adenocarcinoma , epigenetics , cancer research , cancer , survival analysis , metastasis , oncology , medicine , gene , bioinformatics , genetics
We report here that CBX3 (Chromobox 3) may be an independent prognostic biomarker in lung adenocarcinoma (LUAD). High expression levels of CBX3 are implicated in the cell cycle and p53 pathway, as well as tumor proliferation in LUAD. Copy number alterations are correlated with aberrant CBX3 expression in LUAD .