T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation | Zendy

Chen Mao | Zendy; Li Suting | Zendy; Hao Menglei | Zendy; Chen Jue | Zendy; Zhao Zhihan | Zendy; Hong Shasha | Zendy; Min Jie | Zendy; Tang Jianming | Zendy; Hu Ming | Zendy; Hong Li | Zendy

Open Access

T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation

Author(s) -

Chen Mao,

Li Suting,

Hao Menglei,

Chen Jue,

Zhao Zhihan,

Hong Shasha,

Min Jie,

Tang Jianming,

Hu Ming,

Hong Li

Publication year - 2020

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.12965

Subject(s) - myogenesis , endoplasmic reticulum , blockade , c2c12 , unfolded protein response , skeletal muscle , myocyte , microbiology and biotechnology , chemistry , apoptosis , calcium , calcium channel , medicine , endocrinology , biology , biochemistry , receptor

Loss of T‐type calcium channel (TCC) function has been reported to result in decreased cell viability and impaired muscle regeneration. In this study, we report a novel mechanism whereby TCC blockade promotes ERS and contributes to Ca 2+ homeostasis disorder of endoplasmic reticulum, thereby resulting in mitochondrial‐related apoptotic cell death in C2C12 myotubes and skeletal muscle.

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