Open AccessT‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation
Author(s) -
Chen Mao,
Li Suting,
Hao Menglei,
Chen Jue,
Zhao Zhihan,
Hong Shasha,
Min Jie,
Tang Jianming,
Hu Ming,
Hong Li
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12965
Subject(s) - endoplasmic reticulum , myogenesis , blockade , myocyte , skeletal muscle , microbiology and biotechnology , unfolded protein response , chemistry , calcium , c2c12 , apoptosis , voltage dependent calcium channel , l type calcium channel , calcium channel , endocrinology , biology , biochemistry , receptor , organic chemistry
Loss of T‐type calcium channel (TCC) function has been reported to result in decreased cell viability and impaired muscle regeneration. In this study, we report a novel mechanism whereby TCC blockade promotes ERS and contributes to Ca 2+ homeostasis disorder of endoplasmic reticulum, thereby resulting in mitochondrial‐related apoptotic cell death in C2C12 myotubes and skeletal muscle.