Open AccessPGC‐1α is downregulated in a mouse model of obstructive cholestasis but not in a model of liver fibrosis
Author(s) -
Park Jung Hyun,
Kwak Bong Jun,
Choi Ho Joong,
Kim OkHee,
Hong HaEun,
Lee Sang Chul,
Kim KeeHwan,
You Young Kyoung,
Lee Tae Yun,
Ahn Joseph,
Kim SayJune
Publication year - 2021
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12961
Subject(s) - cholestasis , sod2 , fibrosis , glutathione peroxidase , superoxide dismutase , liver injury , catalase , endocrinology , medicine , peroxisome proliferator activated receptor , antioxidant , biology , chemistry , oxidative stress , biochemistry , receptor
Herein, we determined the pathogenesis of cholestatic liver injury in relation to peroxisome proliferator‐activated receptor‐γ co‐activator 1α (PGC‐1α), a potent regulator of energy metabolism and mitochondrial biogenesis. We validated that obstructive cholestasis decreases expression of PGC‐1α, which leads to decreased expression of mitochondrial antioxidant enzymes, thereby rendering mice with cholestatic livers vulnerable to reactive oxygen species (ROS)‐induced cell death.