Open AccessTrifluoperazine induces cellular apoptosis by inhibiting autophagy and targeting NUPR1 in multiple myeloma
Author(s) -
Li Anmao,
Chen Xuanxin,
Jing Zizi,
Chen Jianbin
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12960
Subject(s) - trifluoperazine , autophagy , apoptosis , cancer research , programmed cell death , cell culture , viability assay , chemistry , microbiology and biotechnology , biology , pharmacology , calmodulin , biochemistry , genetics , enzyme
Multiple myeloma is the second most common hematological malignancy. Trifluoperazine (TFP), an antipsychotic drug, has been reported to exert antitumor effects. Here, our results indicate that TFP targets NUPR1, inhibiting cell growth and inducing apoptosis by autophagy inhibition in multiple myeloma cells. This study provides more directions for the treatment for multiple myeloma.