Open AccessADAMTS7 degrades Comp to fuel BMP2‐dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas
Author(s) -
Wang Chao,
Chen Yunqing,
Xiang Hongfei,
Wu Xiaolin,
Tang Qian,
Ma Xuexiao,
Zhang Lu
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12939
Subject(s) - cartilage oligomeric matrix protein , cancer research , bone morphogenetic protein 2 , osteosarcoma , thrombospondin , adamts , cell growth , medicine , metalloproteinase , chemistry , matrix metalloproteinase , pathology , osteoarthritis , in vitro , biochemistry , alternative medicine
Loss of differentiation and lack of osteoblast marker expression are prominent features of osteosarcoma (OS). Here, we report that the expression of metalloproteinase ADAMTS7 is decreased in OS tissues and associated with adverse OS clinical outcomes. Moreover, we showed ADAMTS7 can bind and degrade cartilage oligomeric matrix protein to induce osteogenic differentiation and inhibit an OS malignant phenotype in a bone morphogenetic protein 2‐dependent manner.