Open AccessHyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF‐κB pathway
Author(s) -
Xu Tao,
Wu Xiao,
Zhou Zhou,
Ye Yu,
Yan Chaoting,
Zhuge Nanshan,
Yu Jinhua
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12937
Subject(s) - hyperoside , nf κb , chemistry , microbiology and biotechnology , pharmacology , western blot , signal transduction , mesenchymal stem cell , medicine , rutin , biology , biochemistry , gene , antioxidant
Hyperoside has been reported to possess anti‐inflammatory properties. Here, we confirmed that hyperoside exhibits potential therapeutic properties against periodontitis via promotion of proliferation and osteogenic differentiation of rat bone mesenchymal stem cells through activation of the NF‐κB signaling pathway. Therefore, our study provides evidence that hyperoside may have potential as a novel therapeutic option for periodontitis treatment.