Open AccessRetracted: The F‐box protein FBXO11 restrains hepatocellular carcinoma stemness via promotion of ubiquitin‐mediated degradation of Snail
Author(s) -
Shao Lijiang,
Zhang Xuehui,
Yao Qi
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12933
Subject(s) - snail , cancer research , f box protein , epithelial–mesenchymal transition , hepatocellular carcinoma , protein degradation , ubiquitin , cell , chemistry , ubiquitin ligase , cancer , biology , medicine , metastasis , biochemistry , gene , ecology
FBXO11 expression is down‐regulated in various tumors, but its role in hepatocellular carcinoma remains unclear. Here, we examined the role of FBXO11 in hepatocellular carcinoma cell stemness. FBXO11 overexpression decreased Snail protein levels by directly interacting with Snail and promoting Snail degradation through the ubiquitin‐proteasome system. Overexpression of Snail rescued the inhibitory effect of FBXO11 overexpression on cell stemness.