Open AccessHigh‐resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6
Author(s) -
Davies Jonathan R.,
Britton Amy,
Liu Sai Man,
Acharya K. Ravi
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12931
Subject(s) - clostridium botulinum , botulinum neurotoxin , flaccid paralysis , recombinant dna , chemistry , neurotoxin , receptor , binding site , biophysics , microbiology and biotechnology , acetylcholine , biology , toxin , biochemistry , paralysis , pharmacology , medicine , gene , surgery
Botulinum neurotoxins (BoNTs) cause the deadly condition called botulism, but they can be used as therapeutics for a wide range of indications. BoNTs are classified into many different serotypes and subtypes, each with potentially different intoxication properties. Here, we report crystal structures of the receptor‐binding domains from two subtypes (BoNT/A5 and BoNT/A6) and compare their binding sites with previous BoNT/A structures.