High‐resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6 | Zendy

Davies Jonathan R. | Zendy; Britton Amy | Zendy; Liu Sai Man | Zendy; Acharya K. Ravi | Zendy

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High‐resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6

Author(s) -

Davies Jonathan R.,

Britton Amy,

Liu Sai Man,

Acharya K. Ravi

Publication year - 2020

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.12931

Subject(s) - botulinum neurotoxin , neurotoxin , chemistry , clostridium botulinum , computational biology , biophysics , biology , biochemistry , toxin

Botulinum neurotoxins (BoNTs) cause the deadly condition called botulism, but they can be used as therapeutics for a wide range of indications. BoNTs are classified into many different serotypes and subtypes, each with potentially different intoxication properties. Here, we report crystal structures of the receptor‐binding domains from two subtypes (BoNT/A5 and BoNT/A6) and compare their binding sites with previous BoNT/A structures.

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