Open AccessSusceptibility to erastin‐induced ferroptosis decreases during maturation in a human oligodendrocyte cell line
Author(s) -
Hoshino Tomonori,
Yamakado Hodaka,
Takahashi Ryosuke,
Matsuzawa Shuichi
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12923
Subject(s) - oligodendrocyte , microbiology and biotechnology , glutathione , lipid peroxidation , cell culture , glutamate receptor , gpx4 , programmed cell death , biology , cell , homeostasis , chemistry , oxidative stress , biochemistry , apoptosis , genetics , myelin , neuroscience , central nervous system , enzyme , receptor , glutathione peroxidase
Ferroptosis has been implicated in neurological and other disorders. In this study, we found that immature oligodendrocytes were more susceptible to erastin‐induced ferroptosis than mature oligodendrocytes using human oligodendrocyte cell line MO3.13. These findings highlight the usefulness of immature MO3.13 cells in studies of ferroptosis and investigations into neuropathologies that involve oligodendrocytes.