Open AccessThe transmembrane supercomplex mediating the biogenesis of OMPs in Gram‐negative bacteria assumes a circular conformational change upon activation
Author(s) -
Jin Feng
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12922
Subject(s) - bacterial outer membrane , periplasmic space , biogenesis , biology , transmembrane protein , protein subunit , bama , inner membrane , chaperone (clinical) , microbiology and biotechnology , biophysics , biochemistry , membrane , escherichia coli , medicine , receptor , pathology , gene
I present here the interaction network among the subunits of the β‐barrel assembly machinery (BAM) complex (BamA, BamB) and the periplasmic chaperone SurA, as well as the existence of a ternary BamA–BamB–SurA complex. Theoretical structures for the SurA‐BAM complex, which is part of the transmembrane supercomplex involved in the biogenesis of OMPs in Gram‐negative bacteria, were computed to interpret the mechanism.