Open AccessBiochemical determinants of the IGFBP‐3–hyaluronan interaction
Author(s) -
Dorandish Sadaf,
Devos Jonathan,
Clegg Bradley,
Price Deanna,
Muterspaugh Robert,
Guthrie Jeffrey,
Heyl Deborah L.,
Evans Hedeel Guy
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12919
Subject(s) - peptide , amino acid , glycosylation , biochemistry , growth factor , chemistry , peptide sequence , insulin like growth factor binding protein , cd44 , plasma protein binding , receptor , insulin like growth factor , biology , in vitro , gene
Binding of IGFBP‐3 either to humanin (HN) or to the glycosaminoglycan, hyaluronan (HA), is not affected by either glycosylation or reduction. Glycosylated and reduced CD44 is less able than de‐N‐glycosylated and oxidized CD44 to compete with IGFBP‐3 for binding HA.