Down‐regulation of PDGFRβ suppresses invasion and migration in osteosarcoma cells by influencing epithelial–mesenchymal transition | Zendy

Xing Sining | Zendy; Wang Changdong | Zendy; Tang Huying | Zendy; Guo Jiaqi | Zendy; Liu Xing | Zendy; Yi Faping | Zendy; Liu Geli | Zendy; Wu Xiangmei | Zendy

Open Access

Down‐regulation of PDGFRβ suppresses invasion and migration in osteosarcoma cells by influencing epithelial–mesenchymal transition

Author(s) -

Xing Sining,

Wang Changdong,

Tang Huying,

Guo Jiaqi,

Liu Xing,

Yi Faping,

Liu Geli,

Wu Xiangmei

Publication year - 2020

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.12915

Subject(s) - osteosarcoma , epithelial–mesenchymal transition , mesenchymal stem cell , microbiology and biotechnology , cancer research , transition (genetics) , chemistry , biology , biochemistry , gene

Platelet‐derived growth factor receptor beta belongs to the tyrosine kinase family. Platelet‐derived growth factor receptor beta binds to its specific ligand and induces autophosphorylation to activate the downstream phosphatidylinositol 3‐kinase/AKT/mammalian target of rapamycin pathway. The activated pathway molecules then influence the epithelial–mesenchymal transition process by regulating the expression of epithelial–mesenchymal transition‐related proteins, and ultimately regulating tumor metastasis.

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