Open AccessDown‐regulation of PDGFRβ suppresses invasion and migration in osteosarcoma cells by influencing epithelial–mesenchymal transition
Author(s) -
Xing Sining,
Wang Changdong,
Tang Huying,
Guo Jiaqi,
Liu Xing,
Yi Faping,
Liu Geli,
Wu Xiangmei
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12915
Subject(s) - pi3k/akt/mtor pathway , platelet derived growth factor receptor , cancer research , protein kinase b , epithelial–mesenchymal transition , stromal cell , cell growth , biology , platelet derived growth factor , phosphorylation , metastasis , medicine , signal transduction , microbiology and biotechnology , growth factor , receptor , cancer , genetics
Platelet‐derived growth factor receptor beta belongs to the tyrosine kinase family. Platelet‐derived growth factor receptor beta binds to its specific ligand and induces autophosphorylation to activate the downstream phosphatidylinositol 3‐kinase/AKT/mammalian target of rapamycin pathway. The activated pathway molecules then influence the epithelial–mesenchymal transition process by regulating the expression of epithelial–mesenchymal transition‐related proteins, and ultimately regulating tumor metastasis.