Open AccessmiRNA‐765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells
Author(s) -
Lin Wan,
Miao Yu,
Meng Xiangkun,
Huang Ying,
Zhao Wanli,
Ruan Jigang
Publication year - 2020
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12838
Subject(s) - microrna , multiple drug resistance , leucine zipper , transcription factor , apoptosis , suppressor , cancer research , gene , biology , drug resistance , cancer , cancer cell , genetics
Elucidation of the mechanisms underlying multidrug resistance (MDR) is required to ensure the efficacy of chemotherapy against gastric cancer (GC). To investigate this issue, here we identified that microRNA‐765 (miRNA‐765) is up‐regulated both in MDR GC cell lines and in specimens from patients who are not responding to chemotherapy. In addition, down‐regulation of miRNA‐765 increased the sensitivity of GC cells to anticancer drugs, whereas its overexpression had the opposite effect. Moreover, miRNA‐765 suppressed drug‐induced apoptosis and positively regulated the expression of MDR‐related genes. Finally, we showed that the basic leucine zipper ATF‐like transcription factor 2, a tumor suppressor gene, is the functional target of miRNA‐765. In summary, these results suggest that miRNA‐765 may promote MDR via basic leucine zipper ATF‐like transcription factor 2 in GC cells.