Open AccessSexual dimorphisms in the transcriptomes of murine salivary glands
Author(s) -
Mukaibo Taro,
Gao Xin,
Yang NingYan,
Oei Maria S.,
Nakamoto Tetsuji,
Melvin James E.
Publication year - 2019
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12625
Subject(s) - submandibular gland , sexual dimorphism , gene , biology , salivary gland , endocrinology , sublingual gland , medicine , saliva , parotid gland , gene expression , transcriptome , genetics , pathology
Transcriptional profiling identified 933 sexually dimorphic genes out of the 14 371 protein‐coding genes expressed in the three major murine salivary glands: parotid, sublingual, and submandibular. Most (89%) sex‐specific genes were enriched in a single gland, while only 0.5% of the sexually dimorphic genes were enriched in all glands. The sublingual gland displayed a strong male sex bias (94% of sex‐enriched genes), while a sex preference was not obvious in the parotid or submandibular glands. A subset of transcription factor genes was correlated with the expression of gland‐specific, sex‐enriched genes. Higher expression of Cftr chloride and Scnn1 sodium channels in the male submandibular correlated with greater NaCl reabsorption. In conclusion, adult salivary glands display sex‐ and gland‐specific differences in gene expression that reflect their unique functional properties.