Open AccessRetracted: Knockdown of lnc RNA MNX 1‐ AS 1 suppresses cell proliferation, migration, and invasion in prostate cancer
Author(s) -
Li Zongwu,
Wang Fangfei,
Zhang Shibao
Publication year - 2019
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12611
Subject(s) - du145 , gene knockdown , prostate cancer , cancer research , cell growth , long non coding rna , biology , lncap , cancer , apoptosis , rna , gene , biochemistry , genetics
Altered expression of long non‐coding RNA s (lnc RNA s) has been reported in many malignancies, including prostate cancer. However, the role of lnc RNA MNX 1‐ AS 1 in prostate cancer has not been reported. Here, we report that MNX 1‐ AS 1 is expressed in prostate cancer tissues and cells and that si RNA ‐mediated knockdown of MNX 1‐ AS 1 inhibits proliferation, migration, and invasion of prostate cancer DU 145 and PC 3 cells. In addition, down‐regulation of MNX 1‐ AS 1 decreased expression of proliferating cell nuclear antigen, PH ‐3, N‐cadherin, and vimentin, but enhanced expression of E‐cadherin. In conclusion, this is the first report that knockdown of MNX 1‐ AS 1 suppresses prostate cancer cell proliferation, migration, and invasion. We believe that MNX 1‐ AS 1 may be a potential new therapeutic target for prostate cancer patients.