Open AccessYAP 1 overexpression is associated with poor prognosis of breast cancer patients and induces breast cancer cell growth by inhibiting PTEN
Author(s) -
Guo Liwen,
Chen Yutang,
Luo Jun,
Zheng Jiaping,
Shao Guoliang
Publication year - 2019
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12597
Subject(s) - pten , tensin , cancer research , oncogene , cell growth , hippo signaling pathway , cancer , biology , breast cancer , apoptosis , protein kinase b , pi3k/akt/mtor pathway , cell , coactivator , cell cycle , gene , transcription factor , genetics
YES ‐associated protein 1 ( YAP 1) plays a key role as a transcriptional coactivator in the Hippo tumor suppressor pathway. YAP 1 is overexpressed in a variety of cancers and is considered to be encoded by a proto‐oncogene. However, the role of YAP 1 remains debatable, because both gain and loss of YAP 1 expression have both been reported in breast cancer (BC). Here, we found that elevated expression of YAP 1 mRNA in BC was negatively correlated with relapse‐free, distant metastases‐free and overall survival rates. We then knocked down or overexpressed YAP 1 in human BC cells, and examined cell proliferation, apoptosis, and tumorigenic ability in vivo . We identified that YAP 1 promotes cell growth and inhibits cell apoptosis of BC through the phosphatase and tensin homolog deleted on chromosome 10– AKT signaling pathway, and thus suggest that YAP 1 might serve as a new target for inhibiting BC progression.