Open AccessRetracted: The PI 3K/ AKT axis modulates AATF activity in Wilms’ tumor cells
Author(s) -
Jing Peng,
Zou Jiaqiong,
Weng Kegui,
Peng Pei
Publication year - 2018
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12500
Subject(s) - wilms' tumor , gene knockdown , cancer research , in vivo , biology , in vitro , downregulation and upregulation , protein kinase b , pi3k/akt/mtor pathway , apoptosis , microbiology and biotechnology , signal transduction , gene , genetics
Previous studies have reported excessive expression of apoptosis‐antagonizing transcription factor ( AATF ) in various tumors, where it reinforces the generation and development of cancers and is linked to the clinical outcome. Nevertheless, the expression and influence of AATF in Wilms’ tumor ( WT ) is largely unknown. Here, we discovered that AATF expression was markedly increased in WT tissues as compared to the surrounding normal tissues. Elevated levels of AATF expression were related to tumor relapse and pulmonary metastasis, congruent with it being a predictor of clinical outcome in people suffering from WT . Proliferation, invasion, and migration of WT cells were suppressed by knockdown of AATF and promoted by AATF overexpression in vitro . Furthermore, the tumor generation capability of WT cells noticeably decreased after knockout of AATF in vivo . The phosphoinositide‐3‐kinase ( PI 3K)/ AKT pathway modulated the activity of AATF in WT . The findings of our study indicate that AATF expression is increased in WT and can serve as a predictor of clinical outcome; in addition, it may enhance the development of WT via the PI 3K/ AKT axis and may be a promising marker for WT diagnosis and therapy.